Complete blood count-based inflammation indexes and symptom severity in people with bipolar disorder: an analysis based on structural equation modelling
This study provides novel insights into the differential associations of NLR, MLR, and PLR with symptom severity across manic and depressive episodes, underscoring a complex immune-inflammatory dysregulation in BD. Notwithstanding generally small coefficients, our findings suggest that CBC-based ratios may represent accessible indexes to monitor mood state severity. Further investigation into their clinical utility is needed.
Authors
- Pierluca Guzzi (ORCID: https://orcid.org/0000-0002-4029-1303)
- Giuseppe Carrà (ORCID: https://orcid.org/0000-0002-6877-6169)
- Daniele Cavaleri (ORCID: https://orcid.org/0000-0001-5342-9394)
- Cristina Crocamo (ORCID: https://orcid.org/0000-0002-2979-2107)
- Ilaria Riboldi (ORCID: https://orcid.org/0000-0002-8188-800X)
- Francesco Bartoli (ORCID: https://orcid.org/0000-0003-2612-4119)
Institutions
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1007/s00406-025-02129-2
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00