Development of an immunodeficient mouse that allows for conditional ablation of monocytic cells
A novel NSG-MaFIA mouse line was developed that has use in the study of monocytic cells and in the development of better humanized mouse models. Transfusion of human blood cells into cell-depleted NSG-MaFIA mice increased the persistence of the human cells in the circulation, indicating a role for monocytic cells in the removal of xenogeneic cells from immunodeficient mice.
Authors
- Johnson Q. Tran (ORCID: https://orcid.org/0000-0002-5263-6321)
- Alan G. Gutierrez (ORCID: https://orcid.org/0000-0002-8567-9598)
- Alvin Hui (ORCID: https://orcid.org/0000-0001-6027-7958)
- Kirsten M. Auclair (ORCID: https://orcid.org/0000-0002-9694-6196)
- Kevin Lai
- Rachael P. Jackman (ORCID: https://orcid.org/0000-0001-8591-7819)
- Renata Gilfanova (ORCID: https://orcid.org/0000-0001-7466-3489)
- Marcus O. Muench (ORCID: https://orcid.org/0000-0001-8946-6605)
- Guadalupe Rivera-Torruco (ORCID: https://orcid.org/0000-0003-2835-6343)
- Pamela Milani
- Gabrielle P. A. Smith (ORCID: https://orcid.org/0000-0001-5725-5555)
- Emily J. Du (ORCID: https://orcid.org/0009-0001-8561-943X)
- Eva H. Doyle
- K. L. Chung
- Y. Meijer
Institutions
- University of California, San Francisco (US)
- Pacific Research Institute (US)
- Vitalant (US)
- University of San Francisco (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1699385
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 0.00