Ketogenic diet–induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health
The ketogenic diet significantly improved anthropometric and metabolic parameters while concurrently reducing AdoMet and Orexin-A levels. The strong positive correlation between AdoMet and Orexin-A suggests an interaction between methylation status and neuropeptide signaling during metabolic adaptation to ketosis. These findings highlight AdoMet as a potential integrated biomarker of metabolic health and emphasize the relevance of neuro-metabolic regulation in dietary interventions.
Authors
- Salvatore Allocca
- Laura Mosca (ORCID: https://orcid.org/0000-0001-7024-9192)
- Marco La Marra (ORCID: https://orcid.org/0000-0001-7488-8493)
- Marina Porcelli (ORCID: https://orcid.org/0000-0003-0192-1728)
- Girolamo Di Maio (ORCID: https://orcid.org/0000-0001-6305-2092)
- Claudia Casella (ORCID: https://orcid.org/0000-0001-7229-0885)
- Rita Polito (ORCID: https://orcid.org/0000-0003-1313-2574)
- Fiorenzo Moscatelli (ORCID: https://orcid.org/0000-0003-1274-0332)
- Marcellino Monda (ORCID: https://orcid.org/0000-0002-7184-218X)
- Vincenzo Monda (ORCID: https://orcid.org/0000-0002-6083-5814)
- Maria Casillo (ORCID: https://orcid.org/0009-0001-7212-0285)
- Antonietta Monda (ORCID: https://orcid.org/0009-0009-8422-3837)
- Francesca Cadoni
- Giovanni Messina (ORCID: https://orcid.org/0000-0002-1730-7063)
- Antonietta Messina (ORCID: https://orcid.org/0000-0001-8343-432X)
Institutions
- Parthenope University of Naples (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- San Raffaele University of Rome (IT)
- Federico II University Hospital (IT)
- Pegaso University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fphys.2025.1719549
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00