Fatal early-onset checkpoint inhibitor pneumonitis in a patient with advanced squamous-cell lung cancer with underlying pulmonary fibrosis: a case report and review of the literature

This case illustrates that life-threatening CIP can occur after a single dose of ICI in patients with fibrotic ILD. It emphasizes the urgent need for risk-adapted treatment strategies and enhanced monitoring protocols in this high-risk population.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-04
DOI
https://doi.org/10.3389/fonc.2025.1672093
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
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article

Fatal early-onset checkpoint inhibitor pneumonitis in a patient with advanced squamous-cell lung cancer with underlying pulmonary fibrosis: a case report and review of the literature

Anna Rybacka, Daria M. Keller, Barbara Kuźnar-Kamińska, Dagobert Żarczyński
Frontiers in Oncology
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Fatal early-onset checkpoint inhibitor pneumonitis in a patient with advanced squamous-cell lung cancer with underlying pulmonary fibrosis: a case report and review of the literature

Anna Rybacka, Daria M. Keller, Barbara Kuźnar-Kamińska, Dagobert Żarczyński
article en

Abstract

This case illustrates that life-threatening CIP can occur after a single dose of ICI in patients with fibrotic ILD. It emphasizes the urgent need for risk-adapted treatment strategies and enhanced monitoring protocols in this high-risk population.

Frontiers in OncologyVol. 15
Poznan University of Medical Sciences (PL)
Openalex Percentile: Top 54%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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