Combined complement and coagulation activation in ST-elevation myocardial infarction: associations with myocardial injury and dysfunction
In this STEMI cohort, complement activation as measured by TCC was weakly associated with markers of coagulation activation, but the measured markers had no combined relation with the risk of high peak TnT or low LVEF. These findings suggest that while simultaneous activation of complement and coagulation cannot be ruled out, combined high levels of TCC and coagulation markers do not mirror the extent of myocardial injury or dysfunction in STEMI.
Authors
- Geir Øystein Andersen (ORCID: https://orcid.org/0000-0003-1578-6440)
- Ida G. Lunde (ORCID: https://orcid.org/0000-0001-9502-6841)
- Ragnhild Helseth (ORCID: https://orcid.org/0000-0001-5012-9214)
- Sigrun Halvorsen (ORCID: https://orcid.org/0000-0001-7561-7644)
- C Holst Hansen (ORCID: https://orcid.org/0000-0002-7817-011X)
- Ingebjørg Seljeflot (ORCID: https://orcid.org/0000-0003-4071-3358)
- Karsten E. Kluge (ORCID: https://orcid.org/0000-0002-6561-9037)
- Theis Tønnessen (ORCID: https://orcid.org/0000-0002-3479-8669)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1613603
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitetet i Oslo
- Norges Forskningsråd
- Nasjonalforeningen for Folkehelsen