Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition
In conclusion, the restoration of the gut microbiota composition in combination with the strengthening of the small intestine barrier suggests that LHBGRA43 could be used as a general probiotic strain with ameliorative effects on hepatic lipid accumulation and lipotoxicity.
Authors
- Ana Djordjević (ORCID: https://orcid.org/0000-0002-7042-1631)
- Katarina Jončić Savić
- Danijela M. Mišić (ORCID: https://orcid.org/0000-0002-5419-0773)
- Filip Nikolić (ORCID: https://orcid.org/0000-0002-4343-5069)
- Ana Teofilović (ORCID: https://orcid.org/0000-0001-5731-7525)
- Ljupka Gligorovska (ORCID: https://orcid.org/0000-0003-1415-4599)
- Ivana Strahinić (ORCID: https://orcid.org/0000-0002-4426-0918)
- Biljana Bursać (ORCID: https://orcid.org/0000-0003-2225-678X)
- Nemanja Stanisavljević (ORCID: https://orcid.org/0000-0001-5576-1833)
- Danijela Vojnović Milutinović (ORCID: https://orcid.org/0000-0002-2584-5048)
- Miloš Vratarić (ORCID: https://orcid.org/0000-0002-7906-9793)
- Cem Aydoğan (ORCID: https://orcid.org/0000-0003-1547-1297)
- Bojan Pavlović (ORCID: https://orcid.org/0000-0002-4951-4542)
Institutions
- University of Belgrade (RS)
- Botswana Geoscience Institute (BW)
- Institute of Molecular Genetics (RU)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fphar.2025.1688777
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- European Commission