Study protocol of a multicenter, randomized, non-inferiority, open-label study investigating the efficacy of a fixed-dose combination regimen of dapagliflozin/metformin versus co-administered dual therapy based on glycemic control, satisfaction and a

This study, as the first of its kind, will provide comparative data on the efficacy of the dapagliflozin/metformin XR FDC and co-administration of dapagliflozin and metformin XR in terms of glycemic control, patient satisfaction, quality of life and adherence. These data will help clinicians make more informed decisions for patients with type 2 diabetes and may improve medication burden, treatment adherence, and satisfaction.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2025-11-04
DOI
https://doi.org/10.3389/fendo.2025.1690339
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Study protocol of a multicenter, randomized, non-inferiority, open-label study investigating the efficacy of a fixed-dose combination regimen of dapagliflozin/metformin versus co-administered dual therapy based on glycemic control, satisfaction and a

Yinghong Kong, Chen Feng Ji, Ying Wei, Xueqin Wang et al.
Frontiers in Endocrinology
Diabetes Treatment and Management
article

Study protocol of a multicenter, randomized, non-inferiority, open-label study investigating the efficacy of a fixed-dose combination regimen of dapagliflozin/metformin versus co-administered dual therapy based on glycemic control, satisfaction and a

Yinghong Kong, Chen Feng Ji, Ying Wei, Xueqin Wang, Jun Ye, Guang Wang, Jiaxuan Wang, Ping Shi, Lingling Xu, Juan Xu
article en

Abstract

This study, as the first of its kind, will provide comparative data on the efficacy of the dapagliflozin/metformin XR FDC and co-administration of dapagliflozin and metformin XR in terms of glycemic control, patient satisfaction, quality of life and adherence. These data will help clinicians make more informed decisions for patients with type 2 diabetes and may improve medication burden, treatment adherence, and satisfaction.

Frontiers in EndocrinologyVol. 16
Nantong University (CN), Beijing Chao-Yang Hospital, Capital Medical University (CN), Jiangyin People's Hospital (CN), Zhuhai People's Hospital (CN), Second People's Hospital of NanTong (CN), Changshu No.1 People's Hospital (CN), Southern Medical University Shenzhen Hospital (CN), Third People's Hospital of Hefei (CN), Dingxi City People's Hospital (CN), Beijing Chaoyang Emergency Medical Center (CN)
AstraZeneca
Openalex Percentile: Top 56%
Diabetes Treatment and Management
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Study protocol of a multicenter, randomized, non-inferiority, open-label study investigating the efficacy of a fixed-dose combination regimen of dapagliflozin/metformin versus co-administered dual therapy based on glycemic control, satisfaction and a — Yinghong Kong, Chen Feng Ji, et al. · Frontiers in Endocrinology (2025) | TGRS Research Map | TGRS