Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist
The results indicate the feasibility of this in vitro model for both laboratory- and field-based studies, and that inherent differences between deer mice and mice in cell-autonomous innate immune responses and ERV/TE activation can be demonstrated in dermal fibroblasts as well as the animals themselves.
Authors
- Landen Gozashti (ORCID: https://orcid.org/0000-0001-6023-3138)
- Jonathan V. Duong (ORCID: https://orcid.org/0009-0008-1524-0265)
- Anthony D. Long
- Alan G. Barbour (ORCID: https://orcid.org/0000-0002-0719-5248)
- Aqsa Motiwala
- William J. Hotz
Institutions
- University of California, Irvine (US)
- Evolutionary Genomics (United States) (US)
- Robert S. Peabody Museum of Archaeology (US)
- Irvine University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1666789
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Harvard University
- National Institutes of Health
- Faculty of Arts and Sciences