Low expression of SOD and PRX4 as indicators of poor prognosis and systemic inflammation in colorectal cancer
Low SOD and PRX4 expression was associated with aggressive tumor features, poor survival, and heightened systemic inflammation in patients with CRC. Given their association with tumor aggressiveness and systemic inflammation, antioxidant markers such as SOD and PRX4 may serve as supportive prognostic biomarkers to help identify patients at risk of adverse clinical outcomes in CRC.
Authors
- Sang‐Hyun An (ORCID: https://orcid.org/0000-0001-7986-778X)
- Soo‐Ki Kim (ORCID: https://orcid.org/0000-0003-3797-8654)
- Young Wan Kim (ORCID: https://orcid.org/0000-0001-9963-6743)
- Hyejin Do (ORCID: https://orcid.org/0000-0002-3167-3246)
- Kwangmin Kim (ORCID: https://orcid.org/0000-0003-0496-1303)
- Bora Kim (ORCID: https://orcid.org/0000-0002-7843-5106)
- Cheol-Su Kim (ORCID: https://orcid.org/0000-0002-8057-8771)
- Hye Youn Kwon
Institutions
- Korea National University of Transportation (KR)
- Yonsei University (KR)
- Wonju Severance Christian Hospital (KR)
- BayCare Health System (US)
- Jeonju University (KR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fonc.2025.1614092
- Citations
- 1
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81