Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations
The core abuse potential methods that serve U.S. CSA scheduling and global new drug scheduling are generally reliable for many categories of drugs but need to be modified and perhaps supplemented with additional outcome measures to more fully and accurately characterize potential abuse-related risks. This may include behavioral economic assessments in preclinical and clinical studies and a broader range of outcome measures in HAP studies and adverse event assessment in all clinical studies in drug development programs.
Authors
- Ziva D. Cooper (ORCID: https://orcid.org/0000-0001-8001-2332)
- Caitlyn J. Durgin (ORCID: https://orcid.org/0000-0002-8518-3410)
- Ryan K. Lanier
- Brenda M. Gannon (ORCID: https://orcid.org/0000-0003-1428-2400)
- Matthew L. Banks (ORCID: https://orcid.org/0000-0003-4949-5246)
- Justin C. Strickland (ORCID: https://orcid.org/0000-0003-1077-0394)
- Jack E. Henningfield (ORCID: https://orcid.org/0000-0001-8387-0041)
- David J. Heal (ORCID: https://orcid.org/0000-0002-6128-9632)
- Sally L. Huskinson (ORCID: https://orcid.org/0000-0001-8528-0926)
- James K. Rowlett (ORCID: https://orcid.org/0000-0002-4077-5017)
- William E. Fantegrossi (ORCID: https://orcid.org/0000-0001-9964-1593)
- Marion A. Coe
- Wendy J. Lynch (ORCID: https://orcid.org/0000-0003-4420-6150)
- Gregory Thomas Collins (ORCID: https://orcid.org/0000-0002-2499-3356)
- Sandra D. Comer
- Richard A. Meisch
Institutions
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Virginia Commonwealth University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Neurobehavioral Systems (US)
- South Texas Veterans Health Care System (US)
- The University of Texas Health Science Center (US)
- Pinney Associates (United States)
- University of Virginia (US)
- University of Bath (GB)
- University of Arkansas for Medical Sciences (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1177/02698811251378511
- Citations
- 3
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.92