Differential modulation of cisplatin efficacy by montelukast sodium and desloratadine in lung cancer
MLS enhances CIS-induced cytotoxicity and apoptosis in lung cancer cells and modulates redox gene expression, potentially improving therapeutic efficacy. In contrast, DES may attenuate CIS activity through antioxidant gene upregulation. These findings support the potential of MLS as an effective adjuvant in CIS-based lung cancer treatment. However, the antagonistic effect observed with DES highlights the importance of careful evaluation of candidates for drug repurposing.
Authors
- Ömer Faruk Bayrak (ORCID: https://orcid.org/0000-0001-7562-6604)
- Fikrettin Şahi̇n (ORCID: https://orcid.org/0000-0003-1503-5567)
- Büşra Yüksel (ORCID: https://orcid.org/0000-0001-8240-4866)
- Seha Akduman (ORCID: https://orcid.org/0000-0002-9606-6834)
- Didem Seven (ORCID: https://orcid.org/0000-0003-3406-5905)
- Didem Tecimel (ORCID: https://orcid.org/0000-0002-0776-1238)
Institutions
- Yeditepe University (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF BIOLOGY
- Published
- 2025-10-28
- DOI
- https://doi.org/10.55730/1300-0152.2771
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00