Evaluating SH-SY5Y cells as a dopaminergic neuronal model: morphological, transcriptomic, and proteomic insights
While SH-SY5Y cells exhibited dopaminergic characteristics following the blended differentiation protocol, the transient expression of key neuronal markers and the need for continuous external stimuli raised concerns about the stability and functional maturity of these differentiated cells as an in vitro PD model. These findings suggest that SH-SY5Y cells might not fully capture the properties of mature neurons.
Authors
- Murat Kasap (ORCID: https://orcid.org/0000-0001-8527-2096)
- Gürler Akpınar (ORCID: https://orcid.org/0000-0002-9675-3714)
- Mehmet Sarıhan (ORCID: https://orcid.org/0000-0002-1565-5718)
- Elifcan Koçyiğit (ORCID: https://orcid.org/0000-0003-4709-7519)
- Eylül Ece Işlek Camadan (ORCID: https://orcid.org/0000-0002-6722-2623)
Institutions
- Kocaeli Üniversitesi (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF BIOLOGY
- Published
- 2025-10-28
- DOI
- https://doi.org/10.55730/1300-0152.2772
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kocaeli Üniversitesi