Porphyromonas Gingivalis And Fusobacterium Nucleatum Synergistically Promoting Tumor Progression

The occurrence and development of oral squamous cell carcinoma (OSCC) are closely associated with the oral microbiota. Synergistic and antagonistic interactions between various oral pathogens accelerate OSCC progression, significantly limiting patient prognosis. In this study, we investigated the effects and mechanisms of Porphyromonas gingivalis (P. g) and Fusobacterium nucleatum (F. n) on proliferation and migration of human tongue squamous cell carcinoma cells (Cal-27). Results showed that synergistic treatment of P. g and F. n exerted stronger pro-tumor effects on proliferation and migration compared to monotherapies, probably by accelerating the tumor cell cycle and promoting inflammation. This study clarifies the cooperative tumor-promoting role of multiple bacterial species, providing potential therapeutic targets for OSCC in bacterial infection contexts and highlighting the importance of controlling oral microbiota.