Clinical Efficacy Of Hydroxyapatite Containing Toothpaste In Relieving Dentine Hypersensitivity

This double-blind randomized controlled clinical trial aimed to use an evaporative (air) stimulus and a tactile stimulus to investigate the desensitizing efficacy of hydroxyapatite (HAP) containing toothpaste through a 12-week clinical observation. After a 2-week washout period, 129 subjects were enrolled and randomly assigned to three groups in parallel: (1) test group (a commercial Repair & Protect Toothpaste containing HAP, potassium citrate and NaF); (2) a commercially available anti-sensitivity positive control toothpaste (with Bioglass and NaF); (3) a placebo control toothpaste (without HAP and potassium nitrate, with NaF). Subjects daily used the assigned toothpaste for 2 minutes each time and conducted OST examination and hypersensitivity evaluation at 2, 6, 8 and 12 weeks. After 6 weeks of use, the Schiff index of the test toothpaste group and the positive control group was significantly improved compared with the placebo control group (p<0.05), the improvement was 21.52% and 28.70%, respectively. After 8 weeks of use, the Yeaple index of the test toothpaste group and the positive control group was significantly improved compared with the placebo control group (p<0.05), the improvement value was 17.22 and 12.33, respectively. After 8 weeks’ evaluation, all subjects switched to ordinary commercially available fluoride toothpaste, the Schiff index of the test toothpaste group continued to improve after 4 weeks evaluation. The clinical results showed hydroxyapatite containing toothpaste can effectively relieve hypersensitivity in 6 weeks’ usage, and the effect lasts for 4 weeks after discontinuation.