Enhancing The Inhibition Of Dental Erosion With Q@Hmsn

The aim of this study was to analyse the efficacy of quercetin-encapsulated hollow mesoporous silica nanocomposites (Q@HMSNs) on the prevention of dentine erosion. Q@HMSNs were synthesized, characterized, and evaluated for their biocompatibility. A total of 130 dentine specimens were prepared and randomly distributed into 5 treatment groups (n = 26): Deionized water, NaF, Quercetin, HMSN, and Q@HMSN. All groups were submitted to in vitro erosive (4 cycles/d) challenges for 7 days. Then immersed in the respective solutions for 2 min. Subsequently, the specimens were subjected to additional daily erosion cycles for another 7 days. The effects of the materials on dentinal tubule occlusion and demineralized organic matrix(DOM) preservation were examined by scanning electron microscopy. The penetration depth of rhodamine B fluorescein into the etched dentine was assessed using confocal laser scanning microscopy. The erosive dentine loss and release of type I collagen telopeptide were measured. The data were analysed by one-way analysis of variance (ANOVA) with post hoc Tukey’s test (α = 0.05). Q@HMSNs were successfully synthesized. Q@HMSNs effectively occluded the dentinal tubules, resulting in a thicker DOM in the Q@HMSN group. The CLSM images showed more superficial penetration in the HMSN and Q@HMSN groups than in the quercetin, NaF, and DW groups. The Q@HMSN group exhibited a significantly lower EDL and reduced ICTP levelscompared to the other groups (p < 0.05). Q@HMSNs hold promise for inhibiting dentine erosion by promoting tubule occlusion and DOM preservation.