Micro-Ct Evaluation Of Different Xenogeneic Biomaterials In Ridge Preservation

The primary objective of this randomized clinical trial was to compare the volumetric changes and the histological characteristics of newly formed bone in extraction sockets grafted with deproteinized bovine bone mineral (DBBM; Bio-Oss®) or de-mineralized porcine bone matrix (DPBM; THE Graft®). Additionally, the study aimed to assess the quality and quantity of bone regeneration at two specific time intervals (3 and 6 months) following grafting. Thirty-two eligible patients requiring single-tooth extraction (excluding third molars) in the maxilla or mandible were enrolled in this study. Post-extraction cone beam computed tomography (CBCT) scans were performed, and sockets were filled with either DBBM or DPBM, covered with a collagen membrane. Participants were randomized into two groups: DBBM (n=16) and DPBM (n=16). After 3 or 6 months, 32 bone core specimens (8 per group/time point) were harvested for micro-computed tomography (μCT) and histological analysis. Micro-CT analysis revealed no significant differences in newly formed bone volume fraction between groups (P˃.05). Both grafting materials promoted substantial bone regeneration; however, the DPBM group exhibited higher mineralized bone proportions within the defect area. Histological analysis of biopsies collected during implant placement demonstrates progressive increase in new bone formation over time in both groups. Both DBBM and DPBM effectively promote bone regeneration in extraction sockets. Healing duration significantly affects tissue composition in post-extraction sites, with DPBM yielding higher mineralized bone proportions compared to DBBM.