Portable Microwave-Plasma Device Promotes Extraction-Socket Healing In Minipigs

Tooth extraction often leads to complications like bleeding and dry sockets. Current treatments, such as gelatin sponges and antibiotics, have limitations including delayed healing and risks of drug resistance. Microwave plasma (MP) generates reactive oxygen and nitrogen species (RONS) that aid hemostasis and wound repair, but existing MP devices are too bulky for oral use. This study presents a portable MP device designed to enhance healing in extraction sockets. A compact, portable MP device was developed for efficient use in irregular and hard-to-reach areas, with a 6.4 mm diameter and operates efficiently at a low microwave power of 10 W. Its biological effects were assessed in vitro (hemostasis, macrophage polarization, fibroblast activation) and in vivo using rat and minipig tooth extraction models. The device generated a stable plasma jet of 20 mm and long-lasting RONS with just 1 minute of treatment. MP significantly reduced bleeding and hemostasis time compared to commercial materials. It promoted M2 macrophage polarization and stimulated gingival fibroblast activity, accelerating soft tissue healing. In both rat and minipig models, MP improved socket sealing and supported complete bone regeneration, outperforming traditional agents like gelatin sponges. The MP device has been granted patents and has successfully passed third-party safety evaluations. It is currently undergoing regulatory approval to become a Class III medical device. This portable MP device effectively promotes hemostasis, soft tissue repair, and bone healing in extraction sockets. With clear advantages over current treatments, it offers strong potential for clinical dental applications.