Application Of A Novel Nutrition-Screening Tool In Oscc Population

To validate a novel nutrition-screening tool AIWW for oral squamous cell carcinoma (OSCC) patients, addressing limitations of existing tools (NRS-2002, GLIM, ESPEN) in sensitivity and specificity. (Ge et al. AIWW: a new nutrition-screening tool for the oncologic population. Sci China Life Sci. 2023, 66(8), 1831-1840) A single-center retrospective study of 427 OSCC patients (median age: 62.76 ± 11.42 years; 56.0% male) from the POROMS database (2021–2024) was analyzed. AIWW is a new nutritional assessment tool, comprising age, intake, weight loss, and walking decline (yes/no scoring). Using PG-SGA as a criterion, we investigated differences in the assessment of malnutrition in patients with oral cancer among AIWW and three other different methods (NRS-2002, GLIM, ESPEN). Among 427 patients, preoperative malnutrition prevalence was censused to be 41.92% according to PG-SGA, where NRS-2002 (κ = 0.607) showed the most significant consistency with PG-SGA, followed by AIWW (κ = 0.436), while ESPEN (κ = 0.238) had the poorest agreement. Sensitivity was highest for AIWW (0.972) indicating minimal missed diagnoses, where specificity of AIWW (0.504) was acceptable for mistake diagnostic rate evaluation. All methods mentioned above demonstrated significantly statistical differences (p < 0.05). AIWW exhibits high sensitivity in preoperative nutritional risk assessment for OSCC patients, effectively identifying malnutrition, albeit with relatively lower specificity. Compared to other screening tools, AIWW has certain advantages and limitations, serving as a valuable supplementary tool for preoperative nutritional evaluation in OSCC population.