Analysis On Regenerative Endodontic Treatment In Avulsed Immature Permanent Teeth

Dental avulsion presents significant treatment challenges, especially in immature permanent teeth. Regenerative endodontic treatment (RET) has emerged as a promising biological approach to restore pulp vitality and promote root development. This systematic review and meta-analysis evaluated RET outcomes in avulsed immature teeth. We conducted electronic searches in PubMed, Web of Science, Science Direct, Cochrane Library, and Scopus to gather relevant studies. The selected studies were analyzed by the reviewers using a standardized data extraction form for a simplified extraction process. Data extraction was conducted independently by the reviewers. Of the 1566 records found, nine studies were eligible for systematic review, and seven were eligible for meta-analysis. The point estimate for the rate of tooth survival was 71% (95% confidence interval [CI], 57%-85%). Root lengthening was reported in all seven studies, with a total sample of 23 teeth; 96% (95% CI, 85%-100%), Root width was reported in seven studies, with a total sample of 23 teeth; 98% (95% CI, 87%-100%), Apical Closure Apical narrowing was reported in seven studies, with a total sample of 23 teeth; 92% (95% CI, 81%-100%), Periapical radiolucency was reported in three studies, with a total sample of 23 teeth; 78% (95% CI, 67%-89%). RET may offer benefits for managing avulsed immature permanent teeth, including improvements in root wall lengthening and thickening, periapical lesion healing, and apical closure formation. Regenerative therapy might be a promising treatment option for restoring the health and function of avulsed immature permanent teeth.