Gt-F Hydrogel: Photodynamic And Regenerative Multifunctional Adhesive

This study introduces a novel injectable multifunctional hydrogel adhesive with light-controlled antibacterial properties and cell growth promotion, addressing challenges in peri-implantitis management. This study developed a novel injectable multifunctional hydrogel (GT-F hydrogel) for peri-implantitis management. The hydrogel integrates vinylated tannic acid nanoparticles (vTA NPs), photosensitizer chlorin e6 (Ce6), Cu²⁺ ions, transglutaminase (TG), and gelatin. Key components include: vTA NPs: Provide wet adhesion and ROS scavenging. Ce6: Enables light-activated antibacterial activity. Cu²⁺: Promotes angiogenesis and tissue regeneration. TG and gelatin: Ensure biocompatibility and mechanical stability. The hydrogel was prepared by mixing components at optimized concentrations and crosslinking at 45–55°C. Its injectable nature allows precise adaptation to irregular tissue gaps. 1.Antibacterial Efficacy: Light-activated Ce6 rapidly killed bacteria without cellular toxicity. 2.Biocompatibility: The hydrogel supported soft tissue regeneration. 3.ROS Clearance: vTA NPs effectively scavenged excess ROS. 4.Tissue Integration: Cu²⁺ signaling enhanced vascularization and tissue integration. 5.Mechanical Performance: The hydrogel degraded gradually, matching soft tissue ingrowth. The GT-F hydrogel offers a promising solution for peri-implantitis management, combining antibacterial, anti-inflammatory, and regenerative functions. Its injectable design and adaptability enhance clinical utility, with potential applications in broader wound healing contexts.