Salivary Microbiota And Metabolic Variations Linked To Olp Psychiatric Symptoms.

To assess the microbial community and metabolic variations in oral lichen planus (OLP) with psychiatric symptoms and develop more objective treatment strategies. 16S rRNA sequencing was used to evaluate the oral microbial population in a cohort of 105 OLP patients. To further investigate the potential interaction between OLP and psychiatric factors, saliva samples from 64 depressed/anxious OLP patients (D-OLP) and their age-matched healthy controls were selected for 16S rRNA sequencing. The salivary metabolome was also characterized by ultra performance LC-MS. The results of 16S rRNA sequencing showed that significant differences in species classification between OLP patients and healthy controls. The D-OLP group displayed an increased abundance of Pseudomonas as well as dysregulation of associated metabolism activities. Correlation analysis showed that the altered metabolites were involved in the metabolic pathways related to the oral-microbiome-brain axis and affected various physiological processes such as neurotransmitter transmission and oxidative stress, promoting epithelial inflammatory activation and immune responses. These changes ultimately lead to the destruction of the original oral mucosal homeostasis. Psychiatric factors may promote mucosal inflammatory responses through dysbiosis of the microbiota. The dysregulated oral microbiome-related metabolites may significantly affect the pathogenesis of the oral-brain axis in OLP patients.This study provides valuable insights into potential future modalities for elucidating the pathogenesis of OLP, offering a foundation for the development of personalized therapeutic strategies.