Research On The Postbiotics In The Treatment Of Periodontitis

To evaluate the clinical effect of non-surgical periodontal treatment with postbionics. A total of 35 patients aged 20-50 years with stage Ⅲ/Ⅳ periodontitis were enrolled from August 2023 to December 2024. They were divided into postbiotics group and placebo group. One week after supragingival scaling (T0), periodontal probing and subgingival scaling were performed, followed by oral amoxicillin (500 mg, TID) and metronidazole (400 mg, TID) for one week. Postbiotics (dead Lactobacillus paracasei and metabolites) or placebo were administered continuously for 3 weeks. The patients were reexamined 60 days(T1)after subgingival scaling . This study has been reviewed by the ethics committee of the author's unit. After treatment (T1), the probing depth (PD), clinical attachment loss (CAL) and the positive rate of probing bleeding in the two groups were lower than those before treatment (T0) (P<0.05). The difference of PD before and after treatment was statistically significant between the two groups (p<0.01), and the difference of CAL before and after treatment was also statistically significant between the two groups (p=0.0224). There was no significant difference in the positive rate of blood detection between the two groups before the intervention (p=0.1004), but there was significant difference between the two groups after the intervention (p<0.01). Postbiotics adjuvant therapy is helpful to improve the clinical effect of non-surgical periodontal treatment.