Dentistry Polylactic Acid With Mechanical, Thermal, And Biocompatible Properties

In the field of clinical stomatology, the mechanical and thermal properties of polylactic acid (PLA) are insufficient, and inflammation caused by bacterial infection remains a common challenge in oral wound healing. This paper reports a composite based on a copper-based metal organic framework (Cu-MOF) and modified carbon nanotubes (CNTm) synergistically reinforced PLA, which has excellent mechanical, thermal and cytocompatibility and can be used in the field of stomatology. The composite was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), the mechanical properties were evaluated by tensile tests, the antibacterial properties were verified by inhibition zone experiments of Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and the biocompatibility was analyzed by in vitro cytotoxicity test (CCK-8 method) of mouse calvarial preosteoblasts (MC3T3-E1). One-way analysis of variance was used for data statistics (p<0.05). The mechanical and thermal properties of the composite with 2% CNTm/MOFs added were significantly enhanced, and it also had a long-lasting antibacterial effect on Staphylococcus aureus and Escherichia coli, with a cell survival rate of 126%. CNTm interacts with the PLA matrix through hydrogen bonds, which can effectively promote the interfacial bonding between the reinforcing phase group and PLA. The introduction of MOF gives it anti-inflammatory ability, and its integration into the PLA backbone gives it a long-lasting antibacterial effect. Cu-MOF and CNTm synergistically reinforced PLA composites are ideal for stomatological materials due to their multifunctional properties.