Remineralization Of Nanohydroxyapatite Toothpaste On Artificial Hypomineralization

This in vitro study aims to compare the remineralization potential of nanohydroxyapatite and fluoride toothpaste on artificial hypomineralization. Thirty extracted premolars were block-randomized into three groups of 10 specimens: 1) control, 2) toothpaste containing fluoride (1000 ppm), and 3) toothpaste containing nanohydroxyapatite. Artificial hypomineralization was created in all specimens, which were then subjected to 10 days of pH cycling. Toothpaste slurry was applied twice daily for 2 minutes during the 10 days. Data were analyzed using a one-way ANOVA with a post-hoc Tukey HSD test (p = 0.05). The results of this study revealed that the percentage of surface microhardness recovery (%SMHR) after hypomineralization and pH cycling was highest in group 2 (-43.49) and lowest in group 1 (-71.81). Statistical analysis indicated that the control group was significantly different from the other groups (p < 0.01). The nanohydroxyapatite toothpaste group showed no statistically significant difference compared to the fluoride toothpaste group (p > 0.05). Nanohydroxyapatite and fluoride toothpastes promoted remineralization of artificial hypomineralization.