Dynamic Immunotoxicological Effects Of Degradation Products From Dental Magnesium Alloys

The objective of this study is to evaluate the in vivo degradation, osteogenic potential, and systemic immune responses of dental rare earth magnesium alloys, providing a theoretical basis for their clinical application and material modification. Rare earth magnesium alloys were synthesized and characterized through physicochemical analysis. A murine bone defect model was employed to monitor the dynamic degradation process of the material in vivo and to assess the tissue distribution of magnesium and rare earth elements. Flow cytometry and PCR techniques were utilized to analyze the systemic immune responses induced by the degradation products. Rare earth magnesium alloys significantly enhanced bone regeneration in vivo. Following degradation, rare earth elements predominantly accumulated in the cervical draining lymph nodes, with a progressive increase in macrophage content within these lymph nodes. Dental rare earth magnesium alloys not only promote osteogenesis following implantation but also elicit a series of dynamic immune responses within the organism. Macrophages in the draining lymph nodes may play a pivotal role in the metabolism of rare earth elements during their in vivo degradation process.