Laser And Drug Therapy For Erythema Multiforme: A Case Report

This case report details the successful management of severe acute oral erythema multiforme using a combination of laser treatment and pharmacological. A patient presented with a 10-day history of blisters in the mouth and was initially treated with acyclovir ointment, which did not alleviate symptoms. Three days before the visit, the patient developed multiple erosions in the oral mucosa accompanied by significant pain, leading to difficulties in eating. The patient reported no other medical conditions. Examination revealed congestion and erosion of the palatal and tongue mucosa, covered with a white false membrane, as well as blisters and erosion on the lower lip. Treatment: With informed consent, the patient received local Nd-YAG laser treatment was administered alongside the wet compress therapy. Additionally, systemic treatments included loratadine, medrol, and so on. The patient reported significant pain relief immediately after treatment, and one week, nearly all lesions had healed. A follow-up after one month revealed that the oral mucosa was pink and without abnormalities. Erythema multiforme is commonly triggered by infections, with herpes simplex virus (HSV) being a frequent cause. Affected mucosal sites typically include the lips, tongue, and buccal mucosa, where lesions as vesicles that rapidly erode, resulting in pain and hemorragic crusting, which severely affects eating and speaking. Acute Erythema multiforme is usually treated with antihistamines, emollients, topical corticosteroids, and mouthwashes. This case underscores efficacy of integrating laser therapy with conventional medical treatment for the rapid management of severe erythema multiforme.