Global Burden Of Lip And Oral Cancer In Young Adults

This study evaluates the burden and trends of lip and oral cavity cancer among adolescents and young adults (AYAs) aged 15–39 across 204 countries and regions from 1990 to 2021 and project global trends for the next 30 years. Data were obtained from the 2021 Global Burden of Disease (GBD) study. Key epidemiological indicators, including incidence, prevalence, disability-adjusted life years (DALYs) rate, mortality, and age-standardized rates (ASRs) of lip and oral cavity cancer among AYAs from 1990 to 2021, were analysis. The age-period-cohort (APC) model and cross-national inequality analysis assessed the disease burden and trends. The study also examined the impact of smoking, high alcohol consumption, and tobacco chewing. The Bayesian age-period-cohort (BAPC) model projected disease burden trends from 2022 to 2050. From 1990 to 2021, the global burden of lip and oral cavity cancer among AYAs increased, with males, particularly those over 25, experiencing a significantly higher burden. However, in recent years, the disease burden among female has risen more rapidly. High alcohol consumption was the primary contributor, yet after adjusting for smoking, high alcohol consumption, and tobacco chewing, females exhibited a higher burden and predictive models indicate that age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR) will continue rising until 2051. The disease burden among AYAs exhibits significant spatiotemporal and demographic disparities, with an increasing trend in females, highlighting the need for further research on pathogenesis, risk factors, and prevention strategies.