Mmp-9 May Be Mechanism Underlying In Periodontitis With Hypertension

To examine whether serum MMP-9 and blood pressure are concomitantly elevated in spontaneously hypertensive rats (SHRs) with periodontitis and explore the potential mechanism. Thirty-six 12-week-old male SHRs were randomly divided into an experimental periodontitis group (SHR-L, n = 18) and a non-periodontitis group (SHR-C, n = 18). Two weeks later, the SHR-C and SHR-L groups were each randomly divided into three subgroups and received JNJ0966 (a specific inhibitor of MMP-9) by gavage once per day for seven days at doses of 0, 10, and 30 mg/kg (n = 6 in each subgroup). After one week, the noninvasive caudal artery pressure and serum concentrations of MMP-9, TIMP-1, and Ang II were measured. After three weeks of modeling, the MMP-9 levels and the MMP-9/TIMP-1 ratio, the Ang II concentration, and the blood pressure measurement were all significantly higher in the SHR-L-0 group than in the SHR-C-0 group (p< 0.05). After intervention with JNJ0966, blood pressure and serum MMP-9 and Ang II levels were significantly lower in the SHR-C-30 group than in the SHR-C-0 group(p < 0.05). Systemic application of JNJ0966 can significantly reduce the elevated serum MMP-9 and blood pressure observed in SHR with periodontitis.