Waist-To-Hip Ratio And All-Cause Mortality In Periodontitis

With periodontitis' systemic impact noted and WHR-mortality link in such patients unclear, this NHANSE - based study explored their association. A total of 1,786 periodontitis patients, aged 18 years and above, from the NHANSE database (1999-2018) were included in this prospective cohort study. A multivariable Cox model was then employed to analyze factors related to all-cause mortality. Restricted cubic spline analysis was carried out to examine the relationship between WHR and all - cause mortality. Additionally, subgroup analyses explored how factors such as gender, place of birth, and others affected this link. Finally, sensitivity analysis was conducted to ensure the robustness of the results. After adjusting the confounders, WHR was a significant predictor of all - cause mortality, with each 1-unit increase doubling the hazard ratio (HR = 2.00, 95% CI:1.38-2.90, P < 0.001), and factors like place of birth and smoking were also associated with mortality. Restricted cubic spline analysis indicated that WHR ≥2.95 increased mortality risk (P < 0.001), and subgroup analysis revealed an interaction between heart disease/hypertension and WHR. Sensitivity analysis confirmed the consistency of the results. WHR is a key predictor of all - cause mortality in adult periodontitis patients. Multiple factors influence mortality, offering insights for clinical practice and future research.