Preparation Of Piezoelectric Coatings For The Treatment Of Peri-Implantitis

To enhance implant antibacterial efficacy and soft-tissue integration, we fabricate a bioinspired piezoelectric-conductive integrated peri-implant gingiva (PiG), which is based on a flexible piezoelectric film and conductive polymer network. The piezoelectricity of PiG is achieved through the electrospinning of polyvinylidene fluoride/BaTiO3/MXene on the polydopamine modified plasma-activated Ti surface, while the conductive property of PiG is achieved by the in-situ polymerization of 3,4-ethylenedioxythiophene monomers. Under ultrasound irradiation, neutrophils are used to detect the immune effect of PIG;Staphylococcus aureus and Escherichia coli are used to detect its antibacterial ability; NIH-3T3 fibroblasts are used to detect the biocompatibility of PIG; rat dorsal subcutaneous infection model is prepared to detect the antibacterial ability and collagen production ability of PIG. Under ultrasonic irradiation, the PiG can promote the formation of neutrophil extracellular traps and reactive oxygen species, thus achieving a synergistic and efficient piezodynamic killing of Staphylococcus aureus and Escherichia coli. Additionally, the piezoelectricity-enabled electrical stimulation endows the PiG with enhanced fibroblasts adhesion, proliferation, and collagen secretion.As a demonstration, ultrasound irradiation of PiG-grafted Ti implanted in a subcutaneous implantation rat model efficiently eliminates the S. aureus infection and rescues the implant with enhanced soft-tissue integration. The artificial piezoelectric-conductive integrated peri-Implant gingiva can enables efficient bacterial inhibition and soft-tissue integration. The concept of an artificial PiG is anticipated to unlock new avenues for the development of high-performance implant materials, potentially extending their lifespans.