Gelatin-Modified Carbon Nanotubes Promote Collagen And Dentin Remineralization

The compromised integrity of the hybrid layer significantly undermines resin-dentin interface durability, while collagen-mediated remineralization of demineralized dentin represents a promising approach to enhance bonding stability in clinical applications.In this study, the gelatin-polydopamine modified carbon nanotubes (CNT/PDA/Gel) were constructed to promote the bionic remineralization on collagen fibers and dentin surfaces. Micheal addition reaction was used to synthesize CNTs/PDA/Gel nanoparticles, X-ray electron spectrometer analysis, contact angle detection, confocal laser scanning microscope characterization experiments was performed to reveal the mineralization regulation mechanism after pretreatment of collagen model, Scanning Electron Microscopy and Transmission Electron Microscopy were used to evaluate the effect of collagen and dentin remineralization. The results demonstrated that CNT/PDA/Gel adsorbed collagen fiber surfaces, leveraging its high specific surface area and chemical activity to attract calcium and phosphorus ions. This process reduced the interfacial energy between amorphous calcium phosphate (ACP) and collagen, thereby promoting efficient intrafibrillar and interfibrillar mineralization of collagen and dentin. The remineralized dentin exhibited mechanical properties approaching natural levels. This study demonstrated that CNT/PDA/Gel as a pretreatment agent can induce collagen fiber bionic remineralization efficiently in the dentin demineralization region, which provides a theoretical basis for clinical dental hard tissue restorations and has potential in the field of developing new adhesive agents.