Global Prevalence Of Oral Cancer Among Elderly People

This study aims to systematically evaluate the global burden of oral cancer among elderly people. This study analyzed 1990-2021 GBD data to calculate age-standardized incidence, prevalence, mortality, and DALYs, stratified by sex, age, and SDI. Temporal trends were assessed using AAPC, and future projections (2022-2050) were modeled via BAPC, while examining correlations with SDI. Between 1990 and 2021, global age-standardized incidence (ASIR) and prevalence (ASPR) rates of lip and oral cavity cancer (LOCC) among adults aged 45+ showed significant annual increases of 0.35% and 0.77% respectively, while mortality (ASMR) and DALY rates (ASDR) declined by 0.15% and 0.25% per year. The most substantial burden increases occurred in low- and middle-income regions, with East Asia experiencing the sharpest rises in prevalence (+3.40%) and incidence (+1.84%), and Oceania showing the highest mortality (+0.63%) and DALY (+0.65%) increases. In 2021, Palau and Pakistan carried the highest disease burden, while Cabo Verde demonstrated the most significant worsening trends and the US Virgin Islands and France showed the greatest improvements. Males consistently experienced higher burden than females, with tobacco use and behavioral risks identified as primary contributing factors. Future projections suggest continued increases in incidence and prevalence through 2050, with mortality and DALY rates potentially rebounding after initial declines. Targeted prevention efforts should prioritize high-risk male populations aged 45+ and high-burden regions to enable early intervention and reduce the disease burden.