The Application Of Bio-Adaptive Implants In A Bisphosphonate Environment

Development of a biocompatible amino acids implant coating for use in bisphosphonate environments We developed a cationic alternating copolymer implant coating material composed of amino acids, attached it to the implant and titanium plate surfaces by covalent grafting, characterized the chemical structure of the sample surfaces, and verified its biocompatibility in a bisphosphonate environment: we constructed a bisphosphonate rat implant model by intravenous drug administration and tooth extraction, and investigated its cytotoxicity, osteogenicity, angiogenesis, and antimicrobial efficacy in in vivo implantation and in vitro cellular experiments. toxicity, antimicrobial efficacy, promotion of angiogenesis, and osteogenic efficacy were examined in in vivo implantation and in vitro cellular experiment. The experimental results showed that the amino acid-coated material improved in terms of antimicrobial efficacy, pro-angiogenic and osteogenic efficacy in in vivo and in vitro experiments compared with the control group, and demonstrated good biocompatibility in in vitro cellular experiments. Amino acid-coated materials show promising performance in in vivo and in vitro experiments, provide new strategies for implant patients treated with bisphosphonates, and help dentists optimize the selection of clinical indications for dental implants.