Multifaceted “composite” actin nucleator orchestrates polymerization via dynamic assembly
In this issue, Magliozzi et al. (https://doi.org/10.1083/jcb.202505039) describe a novel actin nucleation mechanism involving an Aip5-Bud6-Bni1 "composite nucleator," which binds both the formin-mediated barbed end and Aip5-associated pointed end, enabling coordinated filament elongation and maintaining actin cable thickness.
Authors
- Yansong Miao (ORCID: https://orcid.org/0000-0003-1551-7873)
- Jiecai Han (ORCID: https://orcid.org/0009-0007-6950-4126)
Institutions
- Nanyang Technological University (SG)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1083/jcb.202509234
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, India