Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors
This work characterizes at a single-cell level the Enzalutamide resistant clone and the impact of epigenetic inhibitors on resistance development. This characterization may enable the identification of resistant and non-resistant cells by their gene expression profile.
Authors
- Carmit K. McMullen (ORCID: https://orcid.org/0000-0001-9445-6591)
- Colette Christiansen (ORCID: https://orcid.org/0000-0001-6034-5746)
- Francesco Crea (ORCID: https://orcid.org/0000-0002-4903-2973)
- Wendi Bacon (ORCID: https://orcid.org/0000-0002-8170-8806)
- Priyadarsini Gangadharannambiar (ORCID: https://orcid.org/0009-0009-6265-031X)
- Morgan Howells (ORCID: https://orcid.org/0009-0008-9422-6380)
Institutions
- The Open University (GB)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1093/jpp/rgaf100
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00