Untargeted Serum Metabolomic Profiling Reveals Metabolic Inflammation Induced by <i>Stutzerimonas stutzeri</i> PM101005 Isolated from Atmospheric Particulate Matter

Particulate matter (PM), a major pollutant of air pollution, contains a complex mixture of chemical and biological elements that pose significant threats to human health. Among the biological components, <i>Stutzerimonas stutzeri</i> PM101005 (PMSS), a bacterium isolated from fine dust, has been identified as a contributor to respiratory damage through inflammation. However, the mechanisms underlying its pathogenicity, particularly in comparison to environmental strains such as <i>S. stutzeri</i> (SS), remain unclear. In this study, we aimed to investigate the systemic effects of PMSS by comparing the serum metabolite profiles and inflammatory responses induced by SS and PMSS infections in a mouse model. Mice infected with PMSS exhibited marked alterations in serum metabolites, many of which were associated with enhanced pro-inflammatory signaling and the suppression of anti-inflammatory pathways. These metabolic changes were accompanied by elevated levels of circulating inflammatory cytokines, indicating a link between PMSS infection, metabolic dysregulation, and systemic inflammation. Our findings demonstrate that PMSS-associated bacterium, induces inflammation through modulation of host serum metabolites. This study suggests that PM-induced changes in serum metabolites contribute to inflammation, highlighting the need for further research on the systemic effects of biologically active components within particulate matter.