Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathy
Apremilast improves loss of cardiomyocyte cohesion, enhances localization of DSG2, and reduces arrhythmia in human and/or murine models of ACM ex vivo and in vitro, providing a novel treatment strategy for ACM by preserving desmosome function.
Authors
- Dominik S. Westphal (ORCID: https://orcid.org/0000-0003-4870-9863)
- Jens Waschke (ORCID: https://orcid.org/0000-0003-1182-5422)
- Tomo Šarić (ORCID: https://orcid.org/0000-0001-8344-1095)
- Chris H. Wendt (ORCID: https://orcid.org/0000-0002-0924-8745)
- Orsela Dervishi
- Maria Shoykhet
- Sina Moztarzadeh (ORCID: https://orcid.org/0000-0001-7519-598X)
- Elisabeth Graf (ORCID: https://orcid.org/0000-0002-1119-2285)
- Konstanze Stangner (ORCID: https://orcid.org/0000-0002-4952-5647)
- Sunil Yeruva (ORCID: https://orcid.org/0000-0002-1565-2023)
- Silvana Olivares‐Florez
- Brenda Gerull (ORCID: https://orcid.org/0000-0002-1363-8826)
- Tatjana Williams (ORCID: https://orcid.org/0000-0001-8987-799X)
- Ruth Biller (ORCID: https://orcid.org/0000-0001-5004-7198)
- Soumyata Pathak
- Ni Luh Cathrin Suniasih Wohlfarth
- Janina Kuhnert
- Jens Opsteen
Institutions
- University of Cologne (DE)
- Bundesverband Glaukom-Selbsthilfe (DE)
- München Klinik (DE)
- Universitätsklinikum Würzburg (DE)
- University Hospital Cologne (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1186/s13287-025-04755-y
- Citations
- 1
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Universität zu Köln
- Universitätsklinikum Köln