Development of a RuHAP-Packed-Bed Reactor for Continuous Flow Aerobic Oxidation
The aerobic oxidation of alcohols is valuable but often limited by toxic reagents, waste, and harsh conditions. Using a Ru<sup>3+</sup>-hydroxyapatite (RuHAP)-packed-bed reactor under low-pressure O<sub>2</sub>, we achieved efficient, reproducible oxidations with TONs of >18,000 after two catalyst regenerations. A two-step continuous flow process integrating oxidation and Knoevenagel condensation delivered products in excellent yields, demonstrating a scalable, safe, and sustainable method with high selectivity and mild conditions for fine chemical and pharmaceutical synthesis.
Authors
- Hun Young Kim (ORCID: https://orcid.org/0000-0002-8461-8910)
- Ki‐Young Kwon (ORCID: https://orcid.org/0000-0001-8684-3225)
- Soocheon Lee
- Kyungsoo Oh (ORCID: https://orcid.org/0000-0002-4566-6573)
- Keunyoung Lee (ORCID: https://orcid.org/0000-0002-1390-2391)
Institutions
- International University of Korea (KR)
- Gyeongsang National University (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c03939
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00