Physiologically based pharmacokinetic integrated models for lamotrigine to evaluate drug exposure and optimize dosage during pregnancy, foetal period, postpartum period, and in breastfed neonates
The developed PBPK model successfully simulated LTG exposure throughout pregnancy, the postpartum period and lactation. It also provided recommendations regarding dose optimization and safety.
Authors
- Zhiwei Liu (ORCID: https://orcid.org/0009-0005-2924-2622)
- Yiming Li (ORCID: https://orcid.org/0009-0007-6422-1442)
- Saiya Li (ORCID: https://orcid.org/0009-0004-1710-1999)
- Haitang Xie (ORCID: https://orcid.org/0000-0001-9933-5481)
- Yating Wu (ORCID: https://orcid.org/0009-0009-3032-6996)
- Youjun Chen (ORCID: https://orcid.org/0009-0004-8376-5101)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1002/bcp.70323
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00