Laser-modified titanium surfaces induce sex-dimorphic secretion of angiogenic factors by gingiva-derived mesenchymal stromal cells
This study suggests that laser-modified microchannels on titanium surfaces provide bioactive topographical cues that enhance the secretion of extracellular vesicles enriched with angiogenic factors-particularly CCN1 and EDIL3-by GMSCs, which may play key roles in promoting angiogenesis and supporting early-stage osseointegration.
Authors
- Ting-Han Chang (ORCID: https://orcid.org/0000-0001-8993-5678)
- Hsin‐Han Hou
- Da‐Yo Yuh (ORCID: https://orcid.org/0000-0003-0183-6603)
- Her‐Hsiung Huang (ORCID: https://orcid.org/0000-0002-3729-3527)
- Yi‐Shing Shieh
Institutions
- Tri-Service General Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- Chulalongkorn University (TH)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.jds.2025.09.013
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00