Atypical presentation of systemic lupus erythematosus flare with ileocecal ulceration and lymphadenopathy in a tuberculosis-endemic region

This case highlights that in TB-endemic regions, clinicians should consider lupus enteritis as a differential diagnosis in patients with nonspecific gastrointestinal lesions and lymphadenopathy, even when tuberculosis is a common concern. False-negative ANA ELISA and indeterminate TB-IGRA results can delay diagnosis. Lymphadenopathy, although not included in current lupus classification criteria, may be an important clinical clue for lupus flares.

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Publication Details

Journal
Medicine
Published
2025-10-17
DOI
https://doi.org/10.1097/md.0000000000044964
Primary Topic
Diagnosis and treatment of tuberculosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Atypical presentation of systemic lupus erythematosus flare with ileocecal ulceration and lymphadenopathy in a tuberculosis-endemic region

Huong Tu Lam, Tan A. Nguyen, Nguyen Khoi Huynh, Tien Manh Huynh et al.
Medicine
Diagnosis and treatment of tuberculosis
article

Atypical presentation of systemic lupus erythematosus flare with ileocecal ulceration and lymphadenopathy in a tuberculosis-endemic region

Huong Tu Lam, Tan A. Nguyen, Nguyen Khoi Huynh, Tien Manh Huynh, Tran Vo, Dong‐Hoon Yang
article en

Abstract

This case highlights that in TB-endemic regions, clinicians should consider lupus enteritis as a differential diagnosis in patients with nonspecific gastrointestinal lesions and lymphadenopathy, even when tuberculosis is a common concern. False-negative ANA ELISA and indeterminate TB-IGRA results can delay diagnosis. Lymphadenopathy, although not included in current lupus classification criteria, may be an important clinical clue for lupus flares.

MedicineVol. 104(42)
Ulsan College (KR), Cho Ray Hospital (VN), University of Medicine and Pharmacy at Ho Chi Minh City (VN), University of Ulsan (KR), University Medical Center HCMC (VN)
Openalex Percentile: Top 50%
Diagnosis and treatment of tuberculosis
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