In situ pulmonary thrombosis and pulmonary embolus are distinct thrombotic phenotypes in critically ill patients with COVID-19 Acute Respiratory Distress Syndrome
IST and PE are distinct forms of pulmonary thrombosis. IST originates from the pulmonary vessel wall and is characterized by skewing from an effective immune response to upregulation of Th1, Th2, and Th17 cell pathways.
Authors
- Jan H. von der Thüsen (ORCID: https://orcid.org/0000-0001-9699-4860)
- Katrijn Daenen (ORCID: https://orcid.org/0009-0003-5664-5393)
- Anne E. Wind
- Virgil A. S. H. Dalm (ORCID: https://orcid.org/0000-0001-5945-4435)
- Marieke J. H. A. Kruip (ORCID: https://orcid.org/0000-0002-0265-4871)
- Eric C. M. Van Gorp (ORCID: https://orcid.org/0000-0001-6415-6678)
- Daniel G. Aynekulu Mersha (ORCID: https://orcid.org/0000-0002-0538-2429)
- Boaz Lopuhaä (ORCID: https://orcid.org/0000-0002-9931-0214)
- Hazra S. Moeniralam (ORCID: https://orcid.org/0009-0008-3275-7813)
- Eva K Kempers (ORCID: https://orcid.org/0000-0001-9458-8674)
- Jim Smit
- Bas C. T. van Bussel (ORCID: https://orcid.org/0000-0003-1621-7848)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Willem A. Dik (ORCID: https://orcid.org/0000-0001-5235-3156)
- Anne‐Marije Hulshof (ORCID: https://orcid.org/0000-0001-9688-2324)
- Nicole P. Juffermans (ORCID: https://orcid.org/0000-0002-3039-6574)
- Hester A. Gietema (ORCID: https://orcid.org/0000-0001-7036-3307)
- Matthijs F.M. van Oosterhout
- Henrik Endeman
- Jessica Khyali
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Netherlands Bioinformatics Centre (NL)
- Erasmus MC (NL)
- Maastricht University (NL)
- St. Antonius Ziekenhuis (NL)
- Maastro Clinic (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.jtha.2025.10.021
- Citations
- 1
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 2.01