Mild pancreatic fibrosis with preserved exocrine function and increased visceral adipose tissue in m.3243A>G carriers: A magnetic resonance imaging study
Increased T1 relaxation time and MRE stiffness indicate mild pancreatic fibrosis in m.3243A>G carriers with diabetes, without further evidence of exocrine insufficiency. Visceral fat was increased in m.3243A>G carriers and associated with insulin resistance, implying metabolic dysregulation.
Authors
- Simone Rask Nielsen (ORCID: https://orcid.org/0000-0002-5776-0321)
- Inge Søkilde Pedersen (ORCID: https://orcid.org/0000-0002-9902-8040)
- Søren Schou Olesen (ORCID: https://orcid.org/0000-0003-3916-3168)
- Malene Pontoppidan Stoico
- Anja Lisbeth Frederiksen (ORCID: https://orcid.org/0000-0002-7944-8910)
- Christina Brock (ORCID: https://orcid.org/0000-0002-3381-1884)
- Mimoza Gjela (ORCID: https://orcid.org/0000-0002-8329-3835)
- Kurt Højlund (ORCID: https://orcid.org/0000-0002-0891-4224)
- Jens Brøndum Frøkjær (ORCID: https://orcid.org/0000-0001-8722-0070)
- Asbjørn Mohr Drewes (ORCID: https://orcid.org/0000-0001-7465-964X)
Institutions
- University of Southern Denmark (DK)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Aalborg University (DK)
Publication Details
- Journal
- Molecular Genetics and Metabolism
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.ymgme.2025.109282
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00