Assessing Patient-Reported Financial, Social, and Time Toxicity in Early-Phase Cancer Clinical Trials in Australia Through a Prospective Multicenter Nonrandomized Cohort Study
To our knowledge, PEARLER is the first prospective study to assess TT, FT, and ST in Australian EP-CTs. Although objective time burden was measurable, few patients perceived it as problematic beyond early cycles. FT and ST were commonly reported but remained stable over time. These findings suggest that EP-CT participation may not negatively affect patient-reported quality-of-life domains and provide reassurance for both clinicians and patients considering enrollment.
Authors
- Joseph Descallar (ORCID: https://orcid.org/0000-0002-6919-4865)
- Adam Cooper
- Abhijit Pal (ORCID: https://orcid.org/0000-0002-4600-6569)
- Martin Hong (ORCID: https://orcid.org/0000-0002-2327-4261)
- Weng Ng (ORCID: https://orcid.org/0000-0003-2354-1857)
- Charlotte Lemech (ORCID: https://orcid.org/0000-0002-5399-9431)
- Joe Wei (ORCID: https://orcid.org/0000-0003-1944-1079)
- Christina T. Teng (ORCID: https://orcid.org/0000-0002-3716-8611)
- Praffulla Kumar Dubey
- Andrew Killen (ORCID: https://orcid.org/0000-0002-2273-3753)
- Udit Nindra (ORCID: https://orcid.org/0000-0002-2612-9502)
- Aflah Roohullah (ORCID: https://orcid.org/0000-0002-4480-2529)
- Kate Wilkinson (ORCID: https://orcid.org/0000-0001-9666-2647)
- Grace Scott (ORCID: https://orcid.org/0000-0001-7905-798X)
- J. Tang (ORCID: https://orcid.org/0009-0002-7530-9953)
- Jun Hee Hong (ORCID: https://orcid.org/0000-0002-9977-7471)
- Wei Chua
- Jeneen Attaullah
Institutions
- Camden and Campbelltown Hospitals (AU)
- University of Wollongong (AU)
- Liverpool Hospital (AU)
- Wollongong Hospital (AU)
- UNSW Sydney (AU)
- Prince of Wales Hospital (AU)
- Ingham Institute (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- JCO Oncology Practice
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1200/op-25-00412
- Citations
- 1
- Primary Topic
- Economic and Financial Impacts of Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.13