Rebound hyperammonemia triggered by interruption of renal replacement therapy in adolescent ornithine transcarbamylase deficiency
This case highlights the importance of uninterrupted RRT in managing acute hyperammonemia and suggests that even short pauses in CHDF can provoke clinically significant rebound. Early initiation of RRT, continuous monitoring of ammonia levels, and individualized treatment strategies are critical for optimizing patient outcomes. J. Med. Invest. 72 : 443-446, August, 2025.
Authors
- Sakiko Otani
- Yoshitoyo Ueno
- Taiga Itagaki (ORCID: https://orcid.org/0000-0002-8387-834X)
- Toshiyuki Nunomura
- Natsuki Bando
- Manabu Ishihara (ORCID: https://orcid.org/0000-0003-0983-3976)
- Takuya Takashima
- Minoru Terazawa
- Kazuki Momota
- Kensuke Moriwaki (ORCID: https://orcid.org/0000-0001-5800-597X)
- Hiroki Sato
- Yuki Nakano (ORCID: https://orcid.org/0000-0002-6622-4934)
- Jun Oto (ORCID: https://orcid.org/0000-0003-2591-4178)
- Saki Saijo
Institutions
- Tokushima Prefectural Central Hospital (JP)
- Tokushima University Hospital (JP)
Publication Details
- Journal
- The Journal of Medical Investigation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2152/jmi.72.443
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tokushima