Association of Modifiable Lifestyle and Metabolic Factors With the Risk of Developing Sepsis: 2-Sample Mendelian Randomized Study
Our study demonstrated that genetic predictors of lifestyle (smoking and physical activity), educational level, and metabolic factors (waist circumference and high-density lipoprotein cholesterol) exhibited a causal association with sepsis risk. Future research should further investigate the underlying mechanisms of these associations to inform more effective preventive strategies against sepsis.
Authors
- Kaijin Xu (ORCID: https://orcid.org/0000-0001-8126-5008)
- Feifei Wang (ORCID: https://orcid.org/0000-0002-2351-6873)
- Haifeng Lv (ORCID: https://orcid.org/0000-0003-1527-3522)
- Weina Fan (ORCID: https://orcid.org/0000-0003-4683-6121)
- Guojie Shen (ORCID: https://orcid.org/0000-0002-6324-2838)
- Qingqing Ye (ORCID: https://orcid.org/0000-0002-3262-8965)
- Jing Liu (ORCID: https://orcid.org/0009-0004-1567-5569)
- Yelin Cao (ORCID: https://orcid.org/0009-0006-2988-5297)
- Xiaoliang Wu (ORCID: https://orcid.org/0000-0003-3844-4849)
Institutions
- National Medical Products Administration (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- National Centre for Infectious Diseases (SG)
- South China Institute of Collaborative Innovation (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Interactive Journal of Medical Research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.2196/72244
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00