Ginsenoside Rb1 alleviates atherosclerosis by modulating vascular smooth muscle cell proliferation, foam cell formation, and autophagy
Rb1 mitigates atherosclerosis by inhibiting VSMC proliferation and foam formation through suppression of c-JUN/AP-1-mediated LOX-1 transcription and activation of autophagy. These actions support Rb1 as a promising phytotherapeutic for plaque attenuation and stabilization.
Authors
- Lan-Lan Bu
- Xi‐Long Zheng (ORCID: https://orcid.org/0000-0002-0889-1827)
- Yi Zhong (ORCID: https://orcid.org/0000-0002-7138-5302)
- Min-Hua Guo
- Lingli Xie
- Huifang Yuan (ORCID: https://orcid.org/0009-0003-1252-707X)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- University of Calgary (CA)
- Libin Cardiovascular Institute of Alberta (CA)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.phymed.2025.157503
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39