Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group

This is a prospective validation of the molecular prognostic features of patients with localized EWS receiving standard-of-care therapy on therapeutic clinical trials. Building on previous work, patients with <i>STAG2</i> mutations were at high risk of relapse.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-11-03
DOI
https://doi.org/10.1200/jco-25-00157
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group

Steven G. DuBois, Brian D. Crompton, Patrick J. Leavey, David S. Shulman et al.
Journal of Clinical Oncology
Neuroblastoma Research and Treatments
article

Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group

Steven G. DuBois, Brian D. Crompton, Patrick J. Leavey, David S. Shulman, Jeffrey A. Sparks, Patrick J. Grohar, Damon R. Reed, Natalie DelRocco, Alanna J. Church, Katherine A. Janeway, Cora A. Ricker, Kelly Klega, Jonathan C. Slack, Leo Mascarenhas, Kelly M. Bailey, Ruxu Han, Riaz Gillani, Mark Krailo, Mohammad Tanhaemami, Victoria Bainer, Abigail Ward
article en

Abstract

This is a prospective validation of the molecular prognostic features of patients with localized EWS receiving standard-of-care therapy on therapeutic clinical trials. Building on previous work, patients with <i>STAG2</i> mutations were at high risk of relapse.

Journal of Clinical OncologyVol. 43(35)
Broad Institute (US), University of Southern California (US), Cedars-Sinai Medical Center (US), Boston Children's Hospital (US), Children's Medical Center (US), Nationwide Children's Hospital (US), Cleveland Clinic (US), Memorial Sloan Kettering Cancer Center (US), Harvard University (US), University of Pittsburgh (US), Dana-Farber Cancer Institute (US), Children's Oncology Group (US), Boston Children's Museum (US), C. S. Mott Children's Hospital (US), The University of Texas Southwestern Medical Center (US)
Openalex Percentile: Top 55%
Neuroblastoma Research and Treatments
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