Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group
This is a prospective validation of the molecular prognostic features of patients with localized EWS receiving standard-of-care therapy on therapeutic clinical trials. Building on previous work, patients with <i>STAG2</i> mutations were at high risk of relapse.
Authors
- Steven G. DuBois (ORCID: https://orcid.org/0000-0003-0882-738X)
- Brian D. Crompton (ORCID: https://orcid.org/0000-0001-9404-6621)
- Patrick J. Leavey (ORCID: https://orcid.org/0000-0002-0541-2536)
- David S. Shulman (ORCID: https://orcid.org/0000-0002-5994-2604)
- Jeffrey A. Sparks (ORCID: https://orcid.org/0000-0002-5556-4618)
- Patrick J. Grohar (ORCID: https://orcid.org/0000-0002-1071-4563)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- Natalie DelRocco (ORCID: https://orcid.org/0000-0002-8139-9839)
- Alanna J. Church (ORCID: https://orcid.org/0000-0002-4835-5770)
- Katherine A. Janeway (ORCID: https://orcid.org/0000-0001-6000-3594)
- Cora A. Ricker (ORCID: https://orcid.org/0000-0003-1202-5603)
- Kelly Klega (ORCID: https://orcid.org/0000-0002-3424-2003)
- Jonathan C. Slack
- Leo Mascarenhas (ORCID: https://orcid.org/0000-0001-7790-0777)
- Kelly M. Bailey (ORCID: https://orcid.org/0000-0003-3925-3243)
- Ruxu Han (ORCID: https://orcid.org/0000-0003-0991-2404)
- Riaz Gillani (ORCID: https://orcid.org/0000-0001-8643-2725)
- Mark Krailo (ORCID: https://orcid.org/0000-0002-7608-0698)
- Mohammad Tanhaemami (ORCID: https://orcid.org/0000-0002-6498-1181)
- Victoria Bainer
- Abigail Ward
Institutions
- Broad Institute (US)
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Boston Children's Hospital (US)
- Children's Medical Center (US)
- Nationwide Children's Hospital (US)
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Dana-Farber Cancer Institute (US)
- Children's Oncology Group (US)
- Boston Children's Museum (US)
- C. S. Mott Children's Hospital (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1200/jco-25-00157
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00