Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy
PRLs are common in pediatric MS and are linked to greater lesion burden and gray matter atrophy. These findings suggest that PRLs are promising imaging biomarkers of more severe brain tissue damage although their ability to predict future disability requires confirmation in longer term studies.
Authors
- Sukhvir Wright (ORCID: https://orcid.org/0000-0002-5464-3779)
- Sniya Sudhakar (ORCID: https://orcid.org/0000-0002-7632-9705)
- Ming Lim (ORCID: https://orcid.org/0000-0001-7738-8910)
- Yael Hacohen (ORCID: https://orcid.org/0000-0001-8490-9657)
- Nee Na Kim (ORCID: https://orcid.org/0009-0007-6987-3060)
- Valeria Pozzilli (ORCID: https://orcid.org/0000-0002-0556-0176)
- Arman Eshaghi (ORCID: https://orcid.org/0000-0002-6652-3512)
- Sithara Ramdas (ORCID: https://orcid.org/0000-0003-3790-2190)
- Cheryl Hemingway (ORCID: https://orcid.org/0000-0002-3899-3015)
- Asthik Biswas (ORCID: https://orcid.org/0000-0003-2010-9524)
- Thomas Rossor (ORCID: https://orcid.org/0000-0001-5472-1813)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Ermelinda De Meo (ORCID: https://orcid.org/0000-0001-5531-1111)
- Olga Ciccarelli (ORCID: https://orcid.org/0000-0001-7485-1367)
- Kshitij Mankad (ORCID: https://orcid.org/0000-0001-5979-9337)
- Michael Eyre (ORCID: https://orcid.org/0000-0002-6704-5727)
- Evangeline Wassmer (ORCID: https://orcid.org/0000-0002-2446-1106)
- Mário Sá (ORCID: https://orcid.org/0000-0001-7555-1040)
- Riccardo Nistri (ORCID: https://orcid.org/0000-0002-5479-8201)
- Amitav Parida
- Philip Goebl
Institutions
- Università Campus Bio-Medico (IT)
- Queen Mary University of London (GB)
- Aston University (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Great Ormond Street Hospital (GB)
- John Radcliffe Hospital (GB)
- National Institute for Health and Care Research (GB)
- Birmingham Children's Hospital (GB)
- Laboratoire d’Imagerie Biomédicale (FR)
- Evelina London Children's Healthcare (GB)
- King's College Hospital (GB)
- Institute of the Americas (US)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1212/nxi.0000000000200506
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47