HTLV-1–Specific CTL Accumulation in CSF Contributes to Neuroinflammation in HTLV-1–Associated Myelopathy
HTLV-1-specific CTLs selectively accumulate in the CSF of patients with HAM/TSP. Chronic inflammation, primarily driven by the interaction between proliferating HTLV-1-infected cells and accumulated HTLV-1-specific CTLs, may contribute to neural damage in patients with HAM/TSP.
Authors
- Yujiro Higuchi (ORCID: https://orcid.org/0000-0002-5579-4384)
- Yusuke Sakiyama (ORCID: https://orcid.org/0000-0003-0691-1705)
- Mika Dozono
- Masakazu Tanaka (ORCID: https://orcid.org/0000-0003-4098-385X)
- Daisuke Kodama (ORCID: https://orcid.org/0000-0003-1118-4856)
- Eiji Matsuura (ORCID: https://orcid.org/0000-0001-8215-8853)
- Satoshi Nozuma (ORCID: https://orcid.org/0000-0002-4909-7769)
- Takashi Yoshida (ORCID: https://orcid.org/0000-0002-1516-9613)
- Hiroshi Takashima (ORCID: https://orcid.org/0000-0003-0989-6141)
- Ryuji Kubota (ORCID: https://orcid.org/0000-0002-4158-3471)
- Toshio Matsuzaki
Institutions
- Kagoshima University (JP)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1212/nxi.0000000000200508
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00